The Systems Medicine Seminar welcomes Eirini Tsirvouli, hosted by Dr. Luis Fonseca.
Presenter: Eirini Tsirvouli, Researcher & PhD Candidate
Affiliation: Oncologics & Norwegian University of Science & Technology
Title: Dynamic Boolean modeling of psoriasis
Abstract: Psoriasis is a chronic, inflammatory disease that evolves through complex interactions among keratinocytes and immune cells, leading to uncontrolled inflammation, increased immune activity, and a disrupted keratinocyte life cycle. Despite the availability of several drugs for psoriasis management, the disease remains incurable, leaving many patients suboptimally treated. In this presentation, I will share our work on a Boolean multiscale population model of molecular and signaling interactions in psoriasis. The model integrates discrete logical formalism and stochastic simulations to approximate population dynamics and simulate cell-specific phenotypes. Through simulations and network analysis, the model suggests candidate drug combinations with predicted efficacy comparable to the gold standard in clinical practice.
Date: Thursday March 21, 2024 at 9:00 AM Eastern Time
Venue: This presenter will be conducting the seminar virtually via Zoom. Join by Zoom or in MSB Room M-434, the LSM Conference Room.