The Systems Medicine Seminar welcomes Dr. Adrianne Jenner, hosted by Dr. Helen Moore.
Presenter: Adrianne Jenner, Senior Lecturer, Faculty of Science
Affiliation: School of Mathematical Sciences, Queensland University of Technology
Title: In silico immunology: virtual clinical trials in cancer
Abstract: Using mathematics, we can create in silico (computerised) representations of biology to answer questions about disease aetiology and treatment. In this talk, I’ll present two different ways we use in silico mathematical and computational modelling to build representations of the immune system in cancer. In the first half of the talk, I’ll discuss how we can use mathematics to probe the impact of heterogeneity in mice and humans on a new experimental cancer treatment using an oncolytic virus and bi-specific T-cell engagers. In the second half of the talk, we’ll look at how agent-based models can be used to visualise and optimise T cell expansion for adoptive T cell transfer. From this work, we hope to support experimentalists and clinicians in understanding these exciting new cancer therapies and ultimately improve their efficacy.
Date: Tuesday, November 18, 2025, at 4:00 PM Eastern Time
Venue: This presenter will be conducting the seminar virtually via Zoom. Join by Zoom or in MSB Room M-434, the LSM Conference Room.