Dr. Ali Zarrinpar

Dr. Ali Zarrinpar

Date: Tuesday, July 23, 2024, at 4:00 PM Eastern Time

Join by Zoom:https://ufl.zoom.us/j/96123363118 

Join to view Zoom in person: MSB Room M-434, LSM Conference Room

Speaker: Ali Zarrinpar, MD, PhD, Professor

Affiliation: Department of Surgery, College of Medicine, University of Florida

Title: The Future of Transplant Personalized Pharmacotherapy

Abstract: In this talk, we will delve into the transformative potential of personalized medicine in optimizing immunosuppressive regimens for transplantation. We will systematically explore personalized medicine tools and their applications in immunosuppression, encompassing both well-established and emerging topics in pharmacokinetics, pharmacodynamics, and pharmacogenomics. The discussion will focus on three primary objectives to provide a comprehensive understanding of this field.

Objective 1: We will examine the evidence supporting the role of advanced therapeutic drug monitoring and pharmacogenomics in guiding the personalized dosing of key immunosuppressive agents, such as tacrolimus and mycophenolate. This section will highlight how genetic variations and complex drug interactions influence drug metabolism and efficacy, emphasizing the need for individualized dosing strategies.

Objective 2: The talk will describe the potential of pharmacodynamic biomarkers, the microbiome, and systems pharmacology to achieve personalized pharmacotherapy in transplantation. We will discuss how these emerging tools can provide deeper insights into patient-specific responses to immunosuppressive therapy, enabling more targeted and effective treatment plans.

Objective 3: Finally, we will identify important facilitators and barriers to the clinical implementation of personalized pharmacotherapy tools and techniques. This includes discussing the integration of these tools into clinical practice, addressing potential challenges such as cost, accessibility, and the need for interdisciplinary collaboration.

By the end of this presentation, participants will gain a clear understanding of how personalized medicine can be applied to optimize immunosuppressive regimens, ultimately improving patient outcomes in transplantation.