All Posts by

Cory Brunson

Computational modeling of Sirolimus treatment

Dr. Sandra Tsiorintsoa presented posters at the College of Medicine Celebration of Research and the Emerging Pathogens Institute Research Day. Graphical overview of an Agent-Based Model of the SARS-CoV-2 immune response with Sirolimus: macrophage activity (top left), pneumocyte activity (top center), sirolimus mechanisms (center), NK cell activity (top…

LSM hosts the Orlando Math Circle

As part of their April 10 Day Trip to the University of Florida, the Orlando Math Circle visited the Laboratory for Systems Medicine for the 2-hour mini-symposium “Systems Medicine: A Marriage of Math and Biology”. Dr. Matthew Wheeler gave the keynote address, followed by a presentation “From Network Structure…

From FAIR to CURE

Drs. Reinhard Laubenbacher, Rahuman S. Malik-Sheriff, and T. J. Sego co-authored a perspective article with Herbert M. Sauro and several others just published in npj Systems Biology and Applications. Schematic representation of the CURE guidelines. The guidelines emphasize Credibility understandability, Reproducibility and Extensibility.

Injury-Specific Muscle Regeneration

Drs. Tien Comlecoklu and T. J. Sego co-authored a research article with Megan Haase, Alexa Petrucciani, Shayn Peirce, and Silvia Blemker just published in the Journal of the Royal Society Interface. Fibre cross-section and cellular interaction throughout regeneration simulations for eccentric contraction highlighting fibre hypertrophy, changes in fibre organization and…

Attractor Transitions in Boolean Networks

Drs. Byungjoon Min and Reinhard Laubenbacher are primary and senior author on a research article with Jeehye Choi in the journal Chaos. (a) Wiring diagram of a Boolean network and its Boolean function. (b) State space of the Boolean network and its attractors. (c) Probabilities of remaining within the same…

Mechanistic Models as Hypotheses

Dr. Quindel Jones presents her work to the Biomathematics Seminar. Title: Mechanistic Models as Hypotheses: Integrating Structure and Data from Sickle Cell Disease to Bacterial Infection Abstract: Mechanistic models gain scientific value when treated as testable hypotheses rather than fixed descriptions of biology. I illustrate this idea through two…

Pairing critical points in Reeb graphs

A new TDAverse package developed by Dr. Cory Brunson, in collaboration with graduate research assistants Satyajit Mohanty and Shubham Singh, was just published on the Comprehensive R Archive Network. The rgph package binds R to the ReebGraphPairing Java library, written by Junyi Tu and Paul Rosen, to…

Drs. Sego and Sheriff elected SBML Editors

Drs. T.J. Sego and Rahuman Sheriff have been elected to serve as SBML Editors for the 2026–2028 term. SBML (Systems Biology Markup Language) is an open, community-driven standard used to represent and share computational models in systems biology. They look forward to contributing to the advancement of this…

Nasal Mucus Biomarkers for Olfactory Loss

Dr. Cory Brunson is primary author on a research article with Anil Patel, Sufiya Ali, Maria Villanueva, Jeb Justice, Brian Lobo, Nikita Chapurin, Carl Atkinson, and Jennifer Mulligan in the American Journal of Rhinology & Allergy. Variable importance plot several models of nasal mucus biomarkers of olfactory loss in CRSwNP…

Beyond Boolean Networks

Dr. Reinhard Laubenbacher co-authored a research article with Juliana García Galofre, Mercedes Pérez Millán, Ayelén Galarza Rial, and Alicia Dickenstein in the SIAM Journal on Applied Dynamical Systems.