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Multi-site cytokine predictors of primary graft dysfunction

Dr. Cory Brunson co-authored a research article with Dianna Nord, Carl Atkinson, and other colleagues just published in the Transplant International. Abstract:There is an urgent need to better understand the pathophysiology of primary graft dysfunction (PGD) to develop point-of-care methods predicting those at risk. We utilized a…

A Computational and Experimental Study of mTORC1 and SARS-CoV-2

Drs. Henrique Ribeiro and Reinhard Laubenbacher co-authored a research article with Achyudhan Kutuva, Felipe Lima, Matthew Schaller, and Borna Mehrad just published in the Bulletin of Mathematical Biology. Abstract:The mechanistic target of rapamycin complex 1 (mTORC1) has been implicated in coronavirus pathogenesis, yet its precise role in…

How AI Can Advance Mathematical Biology

Dr. Reinhard Laubenbacher co-authored a research article with Kobra Rabiei, Grzegorz A. Rempala, and Wenrui Hao just published in the Bulletin of Mathematical Biology. Abstract:Mathematical biology has long relied on mechanistic models, including ordinary and partial differential equations, stochastic systems, and agent-based models, to study biological processes…

Spatial modelling of NOTCH signalling

Dr. T. J. Sego co-authored a research article with Francois Chesnais and several others just published in npj Systems Biology and Applications. Abstract:Endothelial cells (ECs) are phenotypically heterogeneous to perform specialised functions across different organs and tissues. Although environmental inputs are considered key drivers, we previously observed…

Modeling cellular deformation and rearrangement

Dr. T. J. Sego co-authored a research article with Sharon B. Minsuk, David M. Umulis, Mary C. Mullins, and James A. Glazier just published open-access in npj Systems Biology and Applications. Abstract:Morphogenesis in early development involves complex and extreme deformations in response to intra- and intercellular forces.

From FAIR to CURE

Drs. Reinhard Laubenbacher, Rahuman S. Malik-Sheriff, and T. J. Sego co-authored a perspective article with Herbert M. Sauro and several others just published in npj Systems Biology and Applications. Abstract:Guidelines for managing scientific data have been established under the FAIR principles, requiring that data be Findable, Accessible,…

Injury-Specific Muscle Regeneration

Drs. Tien Comlecoklu and T. J. Sego co-authored a research article with Megan Haase, Alexa Petrucciani, Shayn Peirce, and Silvia Blemker just published in the Journal of the Royal Society Interface. Abstract:Skeletal muscle regeneration is essential for maintaining muscle health and mobility, making it a key area of…

Attractor Transitions in Boolean Networks

Drs. Byungjoon Min and Reinhard Laubenbacher are primary and senior author on a research article with Jeehye Choi in the journal Chaos. Abstract:Biological systems operate under persistent noise, which can alter system states and induce transitions between attractors. Here, we study the attractor dynamics of Boolean networks focusing…

Nasal Mucus Biomarkers for Olfactory Loss

Dr. Cory Brunson is primary author on a research article with Anil Patel, Sufiya Ali, Maria Villanueva, Jeb Justice, Brian Lobo, Nikita Chapurin, Carl Atkinson, and Jennifer Mulligan in the American Journal of Rhinology & Allergy. Abstract:BackgroundThe mechanisms driving chronic rhinosinusitis with nasal polyps (CRSwNP)-related olfactory loss…

Beyond Boolean Networks

Dr. Reinhard Laubenbacher co-authored a research article with Juliana García Galofre, Mercedes Pérez Millán, Ayelén Galarza Rial, and Alicia Dickenstein in the SIAM Journal on Applied Dynamical Systems. Abstract:Boolean networks can be viewed as functions on the set of binary strings of a given length, described via logical…