Dr. Eirini Tsirvouli

Eirini Tsirvouli

Date: Thursday March 21, 2024 at 9:00 AM Eastern Time

Join by Zoom: https://ufl.zoom.us/j/96123363118

Speaker: Eirini Tsirvouli, Researcher & Ph.D. Candidate

Affiliation: ONCOLOGICS & Norwegian University of Science & Technology

Title: Dynamic Boolean modeling of psoriasis

Abstract: Psoriasis is a chronic, inflammatory disease that evolves through complex interactions among keratinocytes and immune cells, leading to uncontrolled inflammation, increased immune activity, and a disrupted keratinocyte life cycle. Despite the availability of several drugs for psoriasis management, the disease remains incurable, leaving many patients suboptimally treated. In this presentation, I will share our work on a Boolean multiscale population model of molecular and signaling interactions in psoriasis. The model integrates discrete logical formalism and stochastic simulations to approximate population dynamics and simulate cell-specific phenotypes. Through simulations and network analysis, the model suggests candidate drug combinations with predicted efficacy comparable to the gold standard in clinical practice.