Date: November 22, 2022
Speaker: Dr. Mohammad Zahid
Affiliation: H. Lee Moffitt Cancer Center & Research Institute
Title: Modeling Tumor Volume Dynamics to Personalize Radiotherapy for Head and Neck Cancer
Abstract: There is broad clinical interest in deintensification of treatment (surgery, chemotherapy, and radiation) in head and neck cancers, given the high cure rates. However, there has been limited clinical success in uniform treatment de-escalation in this setting, especially with radiotherapy. In this talk, I will present two models of tumor volume dynamics describing individual patient response to radiotherapy and how we use these models to explore the potential for treatment personalization for head and neck cancers. I will introduce: the clinical problem of uniform radiotherapy dosing for head and neck cancer, two models of tumor volume dynamics under radiotherapy, a framework for forecasting individual patient responses, and two mathematical explorations of treatment schedule and dose personalization.