The future of digital twins in precision dentistry.
Saghiri MA, Vakhnovetsky J, Saghiri AM
Journal of oral biology and craniofacial research (2023) 13:19. PMID:36345496 DOI:10.1016/j.jobcr.2022.10.003
ZfA special issue “Digital Human Modeling” -an opening message from the IEA Technical Committee Digital Human Modeling and Simulation
Paul G., IEA Technical Committee Digital Human Modeling and Simulation
Zeitschrift für Arbeitswissenschaft (2022). DOI:10.1007/s41449-022-00338-2
Preparing for the next pandemic: Simulation-based deep reinforcement learning to discover and test multimodal control of systemic inflammation using repurposed immunomodulatory agents
Larie D, An G, Cockrell C.
Frontiers in Immunology (2022) 13. PMID:35194613 DOI:10.3389/fimmu.2022.995395
The AI life cycle: a holistic approach to creating ethical AI for health decisions.
Ng MY, Kapur S, Blizinsky KD, Hernandez-Boussard T
Nature Medicine (2022) 28:2247-2249. PMID:36163298 DOI:10.1038/s41591-022-01993-y
Exploring approaches for predictive cancer patient digital twins: Opportunities for collaboration and innovation.
Stahlberg EA, Abdel-Rahman M, Aguilar B, Asadpoure A, Beckman RA, Borkon LL, Bryan JN, Cebulla CM, Chang YH, Chatterjee A, Deng J, Dolatshahi S, Gevaert O, Greenspan EJ, Hao W, Hernandez-Boussard T, Jackson PR, Kuijjer M, Lee A, Macklin P, Madhavan S, McCoy MD, Mohammad Mirzaei N, Razzaghi T, Rocha HL, Shahriyari L, Shmulevich I, Stover DG, Sun Y, Syeda-Mahmood T, Wang J, Wang Q, Zervantonakis I
Frontiers in digital health (2022) 4:1007784. PMID:36274654 DOI:10.3389/fdgth.2022.1007784
Cambridge Hybrid Closed-Loop System in Very Young Children With Type 1 Diabetes Reduces Caregivers’ Fear of Hypoglycemia and Improves Their Well-Being.
de Beaufort C, Schierloh U, Thankamony A, Ware J, Wilinska ME, Fröhlich-Reiterer E, Kapellen TM, Rami-Merhar B, Hofer SE, Campbell FM, Yong J, Bocchino LE, Sibayan J, Lawton J, Roze S, Fritsch M, Thiele A, Allen JM, Boughton C, Mader JK, Kollman C, Hovorka R, Pit-Ten Cate IM; KidsAP Consortium; KidsAP Consortium
Diabetes Care (2022). PMID:36350787 DOI:10.2337/dc22-0693
COVID-associated pulmonary aspergillosis in immunocompetent patients.
Ribeiro HA, Scindia Y, Mehrad B, Laubenbacher R
BioRxiv (2022). PMID:35898340 DOI:10.1101/2022.07.18.500514
Addressing barriers in comprehensiveness, accessibility, reusability, interoperability and reproducibility of computational models in systems biology.
Niarakis A, Waltemath D, Glazier J, Schreiber F, Keating SM, Nickerson D, Chaouiya C, Siegel A, Noël V, Hermjakob H, Helikar T, Soliman S, Calzone L
Briefings in Bioinformatics (2022) 23. PMID:35671510 DOI:10.1093/bib/bbac212
Drug development digital twins for drug discovery, testing and repurposing: A schema for requirements and development.
An G., Cockrell C.
Frontiers in Systems Biology (2022) 2. PMID:35935475 DOI:10.3389/fsysb.2022.928387
Integrating mechanism-based modeling with biomedical imaging to build practical digital twins for clinical oncology.
Wu C, Lorenzo G, Hormuth DA 2nd, Lima EABF, Slavkova KP, DiCarlo JC, Virostko J, Phillips CM, Patt D, Chung C, Yankeelov TE.
Biophysics Reviews (2022) 3:21304. PMID:35602761 DOI:10.1063/5.0086789
Integrating mechanism-based modeling with biomedical imaging to build practical digital twins for clinical oncology.
Wu C, Lorenzo G, Hormuth DA 2nd, Lima EABF, Slavkova KP, DiCarlo JC, Virostko J, Phillips CM, Patt D, Chung C, Yankeelov TE
Biophysics Reviews (2022) 3:21304. PMID:35602761 DOI:10.1063/5.0086789
Building digital twins of the human immune system: toward a roadmap.
Laubenbacher R, Niarakis A, Helikar T, An G, Shapiro B, Malik-Sheriff RS, Sego TJ, Knapp A, Macklin P, Glazier JA
npj Digital Medicine (2022) 5:64. PMID:35595830 DOI:10.1038/s41746-022-00610-z
Specialty grand challenge: what it will take to cross the valley of death: translational systems biology, true precision medicine, medical digital twins, artificial intelligence and in silico clinical trials
An G.
Frontiers in Systems Biology (2022) 2. DOI:10.3389/fsysb.2022.901159
A virtual host model of Mycobacterium tuberculosis infection identifies early immune events as predictive of infection outcomes.
Joslyn LR, Linderman JJ, Kirschner DE
Journal of Theoretical Biology (2022) 539:111042. PMID:35114195 DOI:10.1016/j.jtbi.2022.111042
Digital twins for predictive oncology will be a paradigm shift for precision cancer care.
Hernandez-Boussard T, Macklin P, Greenspan EJ, Gryshuk AL, Stahlberg E, Syeda-Mahmood T, Shmulevich I
Nature Medicine (2021) 27:2065-2066. PMID:34824458 DOI:10.1038/s41591-021-01558-5
Utilizing the Heterogeneity of Clinical Data for Model Refinement and Rule Discovery Through the Application of Genetic Algorithms to Calibrate a High-Dimensional Agent-Based Model of Systemic Inflammation.
Cockrell C., An G.
Frontiers in physiology (2021) 12:662845. PMID:34093225 DOI:10.3389/fphys.2021.662845
Digital twins for multiple sclerosis.
Voigt I, Inojosa H, Dillenseger A, Haase R, Akgün K, Ziemssen T
Frontiers in Immunology (2021) 12:669811. PMID:34012452 DOI:10.3389/fimmu.2021.669811
Using digital twins in viral infection.
Laubenbacher R, Sluka JP, Glazier JA
Science (2021) 371:1105-1106. PMID:33707255 DOI:10.1126/science.abf3370
The ‘Digital Twin’ to enable the vision of precision cardiology.
Corral-Acero J, Margara F, Marciniak M, Rodero C, Loncaric F, Feng Y, Gilbert A, Fernandes JF, Bukhari HA, Wajdan A, Martinez MV, Santos MS, Shamohammdi M, Luo H, Westphal P, Leeson P, DiAchille P, Gurev V, Mayr M, Geris L, Pathmanathan P, Morrison T, Cornelussen R, Prinzen F, Delhaas T, Doltra A, Sitges M, Vigmond EJ, Zacur E, Grau V, Rodriguez B, Remme EW, Niederer S, Mortier P, McLeod K, Potse M, Pueyo E, Bueno-Orovio A, Lamata P
European Heart Journal (2020) 41:4556-4564. PMID:32128588 DOI:10.1093/eurheartj/ehaa159
A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes.
Breton MD, Kanapka LG, Beck RW, Ekhlaspour L, Forlenza GP, Cengiz E, Schoelwer M, Ruedy KJ, Jost E, Carria L, Emory E, Hsu LJ, Oliveri M, Kollman CC, Dokken BB, Weinzimer SA, DeBoer MD, Buckingham BA, Cherñavvsky D, Wadwa RP; iDCL Trial Research Group
The New England Journal of Medicine (2020) 383:836-845. PMID:32846062 DOI:10.1056/NEJMoa2004736
A generalizable data-driven multicellular model of pancreatic ductal adenocarcinoma.
Aguilar B, Gibbs DL, Reiss DJ, McConnell M, Danziger SA, Dervan A, Trotter M, Bassett D, Hershberg R, Ratushny AV, Shmulevich I
GigaScience (2020) 9. PMID:32696951 DOI:10.1093/gigascience/giaa075
The 2019 mathematical oncology roadmap.
Rockne RC, Hawkins-Daarud A, Swanson KR, Sluka JP, Glazier JA, Macklin P, Hormuth DA, Jarrett AM, Lima EABF, Tinsley Oden J, Biros G, Yankeelov TE, Curtius K, Al Bakir I, Wodarz D, Komarova N, Aparicio L, Bordyuh M, Rabadan R, Finley SD, Enderling H, Caudell J, Moros EG, Anderson ARA, Gatenby RA, Kaznatcheev A, Jeavons P, Krishnan N, Pelesko J, Wadhwa RR, Yoon N, Nichol D, Marusyk A, Hinczewski M, Scott JG
Physical Biology (2019) 16:41005. PMID:30991381 DOI:10.1088/1478-3975/ab1a09
High-resolution computational modeling of immune responses in the gut.
Verma M, Bassaganya-Riera J, Leber A, Tubau-Juni N, Hoops S, Abedi V, Chen X, Hontecillas R
GigaScience (2019) 8. PMID:31185494 DOI:10.1093/gigascience/giz062
The Crisis of Reproducibility, the Denominator Problem and the Scientific Role of Multi-scale Modeling.
An G.
Bulletin of Mathematical Biology (2018) 80:3071-3080. PMID:30194523 DOI:10.1007/s11538-018-0497-0
Imaging biomarker roadmap for cancer studies.
O’Connor JP, Aboagye EO, Adams JE, Aerts HJ, Barrington SF, Beer AJ, Boellaard R, Bohndiek SE, Brady M, Brown G, Buckley DL, Chenevert TL, Clarke LP, Collette S, Cook GJ, deSouza NM, Dickson JC, Dive C, Evelhoch JL, Faivre-Finn C, Gallagher FA, Gilbert FJ, Gillies RJ, Goh V, Griffiths JR, Groves AM, Halligan S, Harris AL, Hawkes DJ, Hoekstra OS, Huang EP, Hutton BF, Jackson EF, Jayson GC, Jones A, Koh DM, Lacombe D, Lambin P, Lassau N, Leach MO, Lee TY, Leen EL, Lewis JS, Liu Y, Lythgoe MF, Manoharan P, Maxwell RJ, Miles KA, Morgan B, Morris S, Ng T, Padhani AR, Parker GJ, Partridge M, Pathak AP, Peet AC, Punwani S, Reynolds AR, Robinson SP, Shankar LK, Sharma RA, Soloviev D, Stroobants S, Sullivan DC, Taylor SA, Tofts PS, Tozer GM, van Herk M, Walker-Samuel S, Wason J, Williams KJ, Workman P, Yankeelov TE, Brindle KM, McShane LM, Jackson A, Waterton JC
Nature Reviews. Clinical Oncology (2017) 14:169-186. PMID:27725679 DOI:10.1038/nrclinonc.2016.162
Biocellion: accelerating computer simulation of multicellular biological system models.
Kang S, Kahan S, McDermott J, Flann N, Shmulevich I.
Bioinformatics (2014) 30:3101-3108. PMID:25064572 DOI:10.1093/bioinformatics/btu498
The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset models.
Palsson S, Hickling TP, Bradshaw-Pierce EL, Zager M, Jooss K, O’Brien PJ, Spilker ME, Palsson BO, Vicini P
BMC Systems Biology (2013) 7:95. PMID:24074340 DOI:10.1186/1752-0509-7-95
The Cell Collective: toward an open and collaborative approach to systems biology.
Helikar T, Kowal B, McClenathan S, Bruckner M, Rowley T, Madrahimov A, Wicks B, Shrestha M, Limbu K, Rogers JA
BMC Systems Biology (2012) 6:96. PMID:22871178 DOI:10.1186/1752-0509-6-96
The visible human project
Ackerman MJ
Proceedings of the IEEE 86:504-511. DOI:10.1109/5.662875
Body Voyage: A Three-Dimensional Tour of a Real Human Body
Tsiaras A
Grand Central Pub, 1997. ISBN-10: 0446520098 ISBN-13: 9780446520096
The visible human male: a technical report.
Spitzer V, Ackerman MJ, Scherzinger AL, Whitlock D
Journal of the American Medical Informatics Association 3:118-130. PMID:8653448 DOI:10.1136/jamia.1996.96236280
Healthcare & Life Sciences – Digital Twin Consortium
https://www.digitaltwinconsortium.org/working-groups/healthcare/
SimTK: Welcome
https://simtk.org/
System Simulation in the Context of MBSE – Simcenter
https://blogs.sw.siemens.com/simcenter/system-simulation-in-the-context-of-mbse/
Visible Human Server
https://web.archive.org/web/20060214190019/http://visiblehuman.epfl.ch/index.php?PHPSESSID=f0db2184f2b4c83ab7e5b34f8322191f