James R. Brown, PhD


Date: June 13, 2023

Venue: Zoom

Speaker: James R. Brown, PhD

Affiliation: Drexel University

Title: Integrative Data Analysis in Drug Discovery

Abstract: The plethora of large-scale, high throughput multi-omics technologies now enable the generation of unprecedented multi-dimensional datasets that characterize, at the molecular level, the clinical status of humans during healthy and diseased conditions. The design of multi-omics studies and interpretation of the resultant complex datasets provides both challenges and opportunities for innovative data analyses. This presentation will cover three examples of human-centric multi-omics analyses, with an emphasis on respiratory diseases, that were published by the global pharmaceutical company, GlaxoSmithKline (GSK). The first example is the analyses of human transcriptomic and genome-wide association studies (GWAS) to find new human-host immunity targets for respiratory infections, with an emphasis on TB. Second, the findings of a series multi-site clinical studies on the dynamics of the lung microbiome in COPD patients will be discussed. The final topic is the expansion of the universe of protein-metabolite interactions using multi-omics data from a well-characterized human inflammatory bowel disease cohort and applying bioinformatics, cheminformatics and machine learning approaches.