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UF Health University of Florida
Laboratory for Systems Medicine Division of Pulmonary, Critical Care & Sleep Medicine
Research Overview

Grants

UF Laboratory for systems medicine

Active Grants

NIH – R01 AI 135128-06

Multiscale modeling of the role of heme during invasive pulmonary aspergillosis

Borna Mehrad, Reinhard Laubenbacher

Details
Capture

NSF – 2424635 eMB

Collaborative Research: A mathematical theory for the biological concept of modularity

Reinhard Laubenbacher

Details
Modularity

NSF – MPS 2325776 eMB

Collaborative Research: Advancing Inference of Phylogenetic Trees and Networks under Multispecies Coalescent with Hybridization and Gene Flow

Adam C. Knapp

Details
Annotated graphic of a phylogenetic tree

UF – DRPD-ROSF2024

Optimizing Cancer Therapies in Rare Melanoma Variants: From Kennel to Beside

Helen Moore, Rowan Milner, Bently Doonan

Details
Diagram of population interactions in a canine melanoma model

NIH – K25 AI 175668-01A1

Tuning Complement-Mediated Immunity in Aspergillosis: A Systems Medicine Approach

Luis Sordo Vieira

Details
K25

NIH – R01 HL 169974-01

Mechanistic Modeling of the Innate Immune Responses of the Human Lung to Understand the Inter-Individual Heterogeneity of COVID-19 Pneumonia

Borna Mehrad, Reinhard Laubenbacher

Details
ro1

UF – IC3 AI2Heal Catalyst Grant

Persistent Homology and Machine Learning of Radiological Images for Characterization and Prediction of Interstitial Lung Disease

Jason Cory Brunson, Bruno Hochhegger, Hubert Wagner

Details

UF Laboratory for systems medicine

Completed Grants

R Consortium – ISC Grant 2024-1

Modular, interoperable, and extensible topological data analysis in R

Jason Cory Brunson, Aymeric Stamm

Details
TDAverse and other R package universes

NIH – R01 AI 135128-01

Multiscale Modeling of the Battle Over Iron in Invasive Lung Infection

Reinhard Laubenbacher, Borna Mehrad

Details
simple intracellular model of type II epithelial cells, macrophages, and neutrophils under Aspergillus fumigatus infection

DARPA – W911NF2210040

Precision Immunology: Building an Immune Digital Twin

Reinhard Laubenbacher

Details
development of medical digital twins through collaboration by biologists, clinicians, and computational modelers

NIH – R01 GM 127909-01

Control of Heterogeneous Microbial Communities Using Model-Based Multiobjective Optimization

Reinhard Laubenbacher

Details
Figure 4a from DOI: 10.1073/pnas.2024287118

NIH – U01 EB 024501-01

Modular Design of Multiscale Models, with an Application to the Innate Immune Response to Fungal Respiratory Pathogens

Reinhard Laubenbacher

Details
Histologic image of alveoli surrounding small airways by leukocytes in gp91[phox]-deficient, but not wild-type, mice

DARPA – HR00112220038

GATASD: Generalized Algebraic Techniques Advancing Scientific Discovery

James Fairbanks

Details
Fairbanks – Generalized Algebraic Techniques Advancing Scientific Discovery

NIH – UL1 TR 001427-08S1

Efficient Modeling of Individualized COVID-19 Mortality Risk

Jason Cory Brunson

Details
risk stratification mapper of CCU patients in MIMIC-III

nIH – TL1 TR 001428, UL1 TR 001427

A TL1 Team Approach to Topological Data Analysis for Interpretation of Medical Images and Risk Stratification in COVID-19

Yara Skaf

Details
1-s2.0-S1532046422000983-gr15

US ARO – W911NF-24-1-0125

Research in Biomathematics: A Guide to Funding from the U.S. Army Research Office

Reinhard Laubenbacher, Luis Sordo Vieira

Details
image from a flier for the workshop "Research in Biomathematics: A Guide To Funding From the U.S. Army Research Office"