News and Events


Impact of Hoarding and Obsessive-Compulsive Disorder Symptomatology on Quality of Life and Their Interaction With Depression Symptomatology

Hoarding disorder (HD) is a psychiatric condition characterized by difficulty discarding items and accumulation of clutter. Although studies have established the negative impact of HD and compulsive hoarding behavior, fewer have examined the impact on quality of life (QoL) of hoarding behavior independent of obsessive-compulsive disorder (OCD).



Predictors of professional burnout and fulfilment in a longitudinal analysis on nurses and healthcare workers in the COVID-19 pandemic

To investigate the vulnerability of nurses to experiencing professional burnout and low fulfilment across 5 months of the COVID-19 pandemic. (2) To identify modifiable variables in hospital leadership and individual vulnerabilities that may mitigate these effects.



Plasmodium knowlesi Cytoadhesion Involves SICA Variant Proteins

Plasmodium knowlesi poses a health threat throughout Southeast Asian communities and currently causes most cases of malaria in Malaysia. This zoonotic parasite species has been studied in Macaca mulatta (rhesus monkeys) as a model for severe malarial infections, chronicity, and antigenic variation.



A feasibility study on yoga’s mechanism of action for chronic low back pain: psychological and neurophysiological changes, including global gene expression and DNA methylation, following a yoga intervention for chronic low back pain

Yoga has been shown to reduce pain and improve function in populations with chronic low back pain (cLBP)



Toward Tidy Principles For Matrix-Decomposed Data

On August 8, Cory Brunson will present as part of an invited panel on New Developments in Graphing Multivariate Data at the Joint Statistical Meetings in Washington DC.


Keynote Presentation

Multiscale Computational Models For Lung Immunity

On July 11, Reinhard Laubenbacher will present at the 30th Conference on Intelligent Systems for Molecular Biology of the International Society for Computational Biology in Madison, WI.


Oral presentation

Toward a tidy package ecosystem for topological data analysis

In a special session on Expanding Tidyverse on June 23, Cory Brunson will discuss an open-source R package collection for TDA at the all-virtual useR! 2022.


Workshop at Banff

Decomposition Theories for Discrete Dynamical Systems: An Approach to Modularity of Biological Systems

The Banff International Research Station hosted this workshop from May 29, 2022 to June 5, 2022. Reinhard Laubenbacher and Matt Wheeler joined collaborators for a to work on developing a mathematical foundation for a theory of modularity of biological systems and completed a manuscript on their work.


Recent Publication

Evaluation Framework for Systems Models

Digital twins, customized simulation models pioneered in industry, are beginning to be deployed in medicine and healthcare, with some major successes, for instance in cardiovascular diagnostics and in insulin pump control.



Topological Data Analysis in Biomedicine: A Review

Significant technological advances made in recent years have shepherded a dramatic increase in utilization of digital technologies for biomedicine– everything from the widespread use of electronic health records to… 


Oral Presentation

Post-Transplant Disparities Amongst Sarcoidosis-Indicated Lung Recipients

On Wednesday, May 18, Cory Brunson will give an oral presentation in a mini-symposium on Advances in Pre- and Post-Lung Transplant Care: From Selection to CLAD at the American Thoracic Society International Conference in San Francisco, CA.



Student Research Symposium

May 10, 2022 • 4:00 – 5:30

Cardiology Conference Room, Laboratory for Systems Medicine

Student Research Symposium


Self-reporting of psychiatric illness in an online patient registry is a good indicator of the existence of psychiatric illness

Online registries offer many advantages for research, including the ability to efficiently assess large numbers of individuals and identify potential participants for clinical trials and genetic studies.



Multi-scale mechanistic modelling of the host defence in invasive aspergillosis reveals leucocyte activation and iron acquisition as drivers of infection outcome

Aspergillus species are ubiquitous environmental moulds, with spores inhaled daily by most humans.


2022 Sue Geller Undergraduate Lecture

Medical Digital Twins: Mathematics for 21st Century Medicine

On April 12 at 18:00, Reinhard Laubenbacher will deliver the 2022 Sue Geller Undergraduate Lecture at Texas A&M University.


View More