This project addresses an important biomedical problem: how to control biofilms formed by Candida albicans, a dimorphic fungus that is an important cause of both topical and systemic fungal infection in humans, in particular immunocompromised patients. It is responsible for 85-95% of all vaginal infections resulting in doctor visits. C. albicans biofilms also form on the surface of implantable medical devices, and are a major cause of nosocomial infections. In recent years, it has been recognized that interactions with bacterial species integrated into biofilms can affect C. albicans virulence and other properties, It is therefore important to understand the interactions of C. albicans with bacterial species, in particular metabolic interactions. The next step then is to understand and, ultimately, control how varying compositions of the different microbial species affect their metabolic state and their ability to form biofilms.
- National Institutes of Health 1R01GM127909-01; 4/1/2018-3/31/2022.
- Koshy-Chenthittayil, Sherli; Archambault, Linda; Senthilkumar, Dhananjai; Laubenbacher, Reinhard; Mendes, Pedro; Dongari-Bagtzoglou, Anna. 2021. “Agent Based Models of Polymicrobial Biofilms and the Microbiome—A Review” Microorganisms 9, no. 2: 417. https://doi.org/10.3390/microorganisms9020417