Predicting Populations At-Risk of Developing Pathological Hoarding

Luis Sordo Vieira, Ph.D., Carol A. Mathews M.D.

Hoarding Disorder (HD), recognized as an independent illness in the Diagnostic and Statistical Manual of Mental Disorders for less than a decade, is a debilitating psychiatric disorder with profound socioeconomic impacts. Emerging data shows that hoarding severity correlates with substantial medical burden. Prevalence of clinically significant hoarding behavior is estimated to be between 2 and 4%, with a higher burden in the older population. However, it is believed that hoarding disorder is underdiagnosed. The parent R01MH117114 combines in-person clinical, neuropsychological, and medical frailty assessments with a unique resource, the online Brain Health Registry (BHR), to assess the extent of disability in older adults suffering with hoarding symptoms. We will apply statistical inference and techniques from artificial intelligence to identify predictors of various trends of hoarding symptomatology to find predictors of developing severe hoarding symptoms.



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Sordo Vieira L, Guastello A, Nguyen B, Nutley SK, Ordway A, Simpson H, Zakrzewski J, Archer C, Liu N, Jean Gilles ME, Nosheny R, Weiner M, Mackin RS, Mathews CA. Identifying psychiatric and neurological comorbidities associated with hoarding disorder through network analysis. J Psychiatr Res. 2022 Dec;156:16-24. doi: 10.1016/j.jpsychires.2022.09.037. Epub 2022 Sep 27. PMID: 36219904.

Nguyen BK, Zakrzewski JJ, Sordo Vieira L, Mathews CA. Impact of Hoarding and Obsessive-Compulsive Disorder Symptomatology on Quality of Life and Their Interaction With Depression Symptomatology. Front Psychol. 2022 Aug 1;13:926048. doi: 10.3389/fpsyg.2022.926048. PMID: 35978775; PMCID: PMC9376220.

Sordo Vieira L, Nguyen B, Nutley SK, Bertolace L, Ordway A, Simpson H, Zakrzewski J, Jean Gilles ME, Nosheny R, Weiner M, Mackin RS, Mathews CA. Self-reporting of psychiatric illness in an online patient registry is a good indicator of the existence of psychiatric illness. J Psychiatr Res. 2022 Jul;151:34-41. doi: 10.1016/j.jpsychires.2022.03.022. Epub 2022 Apr 15. PMID: 35436704.


R01 MH117114-03S2: Predicting Populations At-risk of Developing Pathological Hoarding