February 23-24, 2023
UF Health Research and Academic Center, Orlando, FL
Sponsors:
- U.S. Department of Defense, Army Research Office, Biomathematics Program
- Department of Medicine, University of Florida
Local Organizers:
Reinhard Laubenbacher, Ph.D.
University of Florida
Borna Mehrad, M.D., Ph.D.
University of Florida
Scientific Committee:
Fred Adler, Ph.D.
University of Utah
Gary An, M.D.
University of Vermont
James Glazier, Ph.D.
Indiana University
Reinhard Laubenbacher, Ph.D.
University of Florida
Borna Mehrad, M.D., Ph.D.
University of Florida
Anna Niarakis, Ph.D.
Université Paris-Saclay
Participants:
Fred Adler, PhD, University of Utah | email
• Summary of conceptual, scientific, practical and ethical challenges and opportunities discussed by other participants in developing medical digital twins
Gary An, MD, FACS, University of Vermont | email
• Axioms of personalized precision medicine
• Summary of the Forum
Filippo Castiglione, PhD, Technology Innovation Institute | email
• Constructing a computational representation of the Immune System: necessities, constituents, and operational aspects, along with proposed approaches for model development
Stephen Eubank, PhD, University of Virginia | email
• Lessons to be learned from other fields about data assimilation
James Glazier, PhD, Indiana University | email
• A theoretical framework for the construction of medical digital twins
Tomas Helikar, PhD, University of Nebraska | email
• Towards a General Purpose Immune Digital Twin
Marti Jett-Tilton, PhD, U.S. Department of Defense | email
• Digital twins for PTSD
Denise Kirschner, PhD, University of Michigan | email
• Models and Tools for building beta versions of digital partners
Reinhard Laubenbacher, PhD, University of Florida | email
• Introduction to the Forum
• Funding discussion
Paul Macklin, PhD, Indiana University | email
• Integration of standardized, reusable descriptions of cell behaviors and interactions
Borna Mehrad, MD, University of Florida | email
• The application of MDTs to the intensive care unit
Beth Moore, PhD, University of Michigan | email
• Immunologic considerations for building MDT
Virginia Pasour, PhD, U.S. Army Research Office | email
• Funding opportunities
Ilya Shmulevich, PhD, Institute for Systems Biology | email
• Patient Digital Twin for Acute Myeloid Leukemia
Amber Smith, PhD, University of Tennessee | email
• Immune heterogeneity in the context of lung infection
Thomas Yankeelov, PhD, University of Texas at Austin | email
• Imaging-based digital twins for oncology
Tjalf Ziemssen, MD, University Hospital Carl Gustav Carus | email
• A digital twin for autoimmune diseases accessible to the patient
Forum Goal:
Following the successful introduction of the digital twin paradigm in industry, the use of medical digital twins, computational models personalized to individual patients, has received much attention in recent years, and first prototypes have been deployed successfully. Due to the central role the immune system plays in a plethora of diseases it deserves special attention. Its complexity makes computational modeling a key technology for translational applications.
During this 2-day event participants will discuss opportunities and obstacles in the development and use of immune digital twins in medicine. The group will determine the outlines and requirements of a research program to make them a reality within a wide spectrum of translational applications. Results will include a journal publication and a report that can be used for several purposes, in particular with public and private funding bodies.