Forum On Precision Immunology: Immune Digital Twins

February 23-24, 2023

UF Health Research and Academic Center, Orlando, FL

Sponsors:

  • U.S. Department of Defense, Army Research Office, Biomathematics Program
  • Department of Medicine, University of Florida

Local Organizers:

Scientific Committee:

Participants:

Fred Adler, PhD, University of Utah | email

Gary An, MD, FACS, University of Vermont | email

Filippo Castiglione, PhD, Technology Innovation Institute | email

Stephen Eubank, PhD, University of Virginia | email

James Glazier, PhD, Indiana University | email

Tomas Helikar, PhD, University of Nebraska | email

Marti Jett-Tilton, PhD, U.S. Department of Defense | email

George Karniadakis, PhD, Brown University | email

Denise Kirschner, PhD, University of Michigan | email

Reinhard Laubenbacher, PhD, University of Florida | email

Paul Macklin, PhD, Indiana University | email

Borna Mehrad, MD, University of Florida | email

Beth Moore, PhD, University of Michigan | email

Anna Niarakis, PhD, Universite Saclay | email

Virginia Pasour, PhD, U.S. Army Research Office | email

Ilya Shmulevich, PhD, Institute for Systems Biology | email

Amber Smith, PhD, University of Tennessee | email

Thomas Yankeelov, PhD, University of Texas at Austin | email

Tjalf Ziemssen, MD, University Hospital Carl Gustav Carus | email

Forum Goal:

Following the successful introduction of the digital twin paradigm in industry, the use of medical digital twins, computational models personalized to individual patients, has received much attention in recent years, and first prototypes have been deployed successfully. Due to the central role the immune system plays in a plethora of diseases it deserves special attention. Its complexity makes computational modeling a key technology for translational applications.

During this 2-day event participants will discuss opportunities and obstacles in the development and use of immune digital twins in medicine. The group will determine the outlines and requirements of a research program to make them a reality within a wide spectrum of translational applications. Results will include a journal publication and a report that can be used for several purposes, in particular with public and private funding bodies.