Fifteen lab members pose in a terraced courtyard before glass doors whose lintel reads "College of Medicine". A gradient of UF dark blue shades the bottom portion.

Laboratory for Systems Medicine

Mathematical and systems modeling approaches to biology, medicine, and health care

The University of Florida Laboratory for Systems Medicine strives to improve human health via the development of mathematical algorithms and innovative data science solutions.

Programs

BioModels

The world’s largest curated repository of mathematical models of biological and biomedical systems.

Digital Twins

Develop digital twin technology and applications to personalized medicine.

Biological Modularity

Mathematical foundations for the modular structure of biological systems.

Immune Response

Multi-scale, mechanistic, and machine learning models of immune responses to infection and injury.

News and updates

T.J. Sego awarded NIH Replication Prize

Award

May 18, 2026

Dr. T.J. Sego has been awarded the NIH Replication Prize (Track 1), “a competition to advance scientific research by collecting ideas and strategies…

Modeling cellular deformation and rearrangement

Publication

May 18, 2026

Dr. T. J. Sego co-authored a research article with Sharon B. Minsuk, David M. Umulis, Mary C. Mullins, and James A. Glazier just published…

Six disk-shaped epiboly illustrations arranged into 2 rows (cross-section view, lateral surface view) and 3 columns (30%, 50%, 75%). The cross-section view depicts yolk upwardly displacing deep cells, which are bounded above by an enveloping layer and from which the yolk is separated by a cytoplasmic layer suffused with syncytial nuclei. The lateral surface view depicts yolk suffused with a network of microtubules in its cytoplasmic layer, being displaced downward by deep cells covered by an enveloping layer.

Computational modeling of Sirolimus treatment

Presentation

April 21, 2026

Dr. Sandra Tsiorintsoa presented posters at the College of Medicine Celebration of Research and the Emerging Pathogens Institute Research…

Several activation/inhibition wiring diagrams in 4 compartments: macrophages, pneumocytes, sirolimus, and NK cells, with a legend matching icons to cell types

Earlier posts

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Mission

The Laboratory for Systems Medicine strives to improve human health via the development of mathematical algorithms and innovative data science solutions.