Welcome to the Laboratory for Systems Medicine

The overarching focus is the development and application of mathematical and computational technology for the improvement of human health.

Systems medicine News


Dramatic Transcriptomic Differences in Macaca Mulatta and Macaca Fascicularis with Plasmodium Knowlesi Infections

Plasmodium knowlesi, a model malaria parasite, is responsible for a significant portion of zoonotic malaria cases in Southeast Asia and must be controlled to avoid disease severity and fatalities.



Optimization of Agent-Based Models Through Coarse-Graining

Optimization and control are important objectives across biology and biomedicine, and mathematical models are a key enabling technology. This paper reports a computational study of model-based multi-objective optimization in the setting of microbial ecology, using agent-based models. This modeling framework is well-suited to the field, but is not…


Recent Publication

The Why and How of Manuscript Review: What Goes Around Comes Around

Aside from conducting research itself, communicating it to the broader mathematical sciences community—as well as the general public—is the most important task that a researcher must accomplish, for the sake of progress within both the mathematical sciences and one’s own career…



Helen Moore Interview

Helen Moore was Associate Director of Quantitative Clinical Pharmacology, Bristol-Myers Squibb in Princeton, New Jersey and recently joined UF as an Associate Professor in the Laboratory for Systems Medicine.

Helen Moore Interview

Upcoming Seminars

October 28, 2021

Dr. Daniel Plaugher

Modeling the Pancreatic Cancer Microenvironment in Search of Control Targets


November 11, 2021

Dr. Jeremy DeBarry

Practical Recommendations for Supporting a Systems Biology Cyberinfrastructure


Current Research Projects

Modular Design of Multi-scale Models

This project seeks to develop a novel approach to the modular design of multi-scale models using virtual machines and a user friendly open-source platform. Availability of biomedical data sets across spatial and temporal scales makes it possible to calibrate complex models that capture integrated processes from the molecular to the whole organism level.


Control of Biofilms

The project addresses an important biomedical problem: how to control biofilms formed by Candida albicans, a dimorphic fungus that is an important cause of both topical and systemic fungal infection in humans, in particular immunocompromised patients.


Battle Over Iron

Multiscale modeling of disease requires the integration of data at various spatiotemporal scales. Extending these models is often challenged by complex computational implementations and interdependencies between components of the model. In this project, we are developing a computational blueprint so that computational models can be developed in a modular fashion, while minimizing interdependencies between model components.


Network methods in biomedical research

Network analysis has gained popularity in systems medicine, though most applications have been “out of the box”. Cutting-edge network science draws from the rich history of graph theory and recent developments in statistical modeling and is aided by the speed, storage, and interoperability of computational resources. These distinctive research projects showcase the broader potential of network methods.

Trajectory image

we are hiring!

We are hiring!

The newly established Laboratory for Systems Medicine at University of Florida Health is focused on computational and mathematical approaches to human health.

Computational Research