Welcome to the Laboratory for Systems Medicine

The overarching focus is the development and application of mathematical and computational technology for the improvement of human health.

Systems medicine News

recent publication

Impact of Hoarding and Obsessive-Compulsive Disorder Symptomatology on Quality of Life and Their Interaction With Depression Symptomatology

Hoarding disorder (HD) is a psychiatric condition characterized by difficulty discarding items and accumulation of clutter. Although studies have established the negative impact of HD and compulsive hoarding behavior, fewer have examined the impact on quality of life (QoL) of hoarding behavior independent of obsessive-compulsive disorder (OCD).

fpsyg-13-926048-g002

RECENT PUBLICATION

Predictors of professional burnout and fulfilment in a longitudinal analysis on nurses and healthcare workers in the COVID-19 pandemic

To investigate the vulnerability of nurses to experiencing professional burnout and low fulfilment across 5 months of the COVID-19 pandemic. (2) To identify modifiable variables in hospital leadership and individual vulnerabilities that may mitigate these effects.

Fig4

Recent Publication

Plasmodium knowlesi Cytoadhesion Involves SICA Variant Proteins

Plasmodium knowlesi poses a health threat throughout Southeast Asian communities and currently causes most cases of malaria in Malaysia. This zoonotic parasite species has been studied in Macaca mulatta (rhesus monkeys) as a model for severe malarial infections, chronicity, and antigenic variation.

fcimb-12-888496-g005

RECENT PUBLICATION

A feasibility study on yoga’s mechanism of action for chronic low back pain: psychological and neurophysiological changes, including global gene expression and DNA methylation, following a yoga intervention for chronic low back pain

Yoga has been shown to reduce pain and improve function in populations with chronic low back pain (cLBP)

Fig3c

UPCOMING/RECENT PRESENTATIONS

ORAL PRESENTATION

Toward Tidy Principles For Matrix-Decomposed Data

On August 8, Cory Brunson will present as part of an invited panel on New Developments in Graphing Multivariate Data at the Joint Statistical Meetings in Washington DC.

biplot-1

Keynote Presentation

Multiscale Computational Models For Lung Immunity

On July 11, Reinhard Laubenbacher will present at the 30th Conference on Intelligent Systems for Molecular Biology of the International Society for Computational Biology in Madison, WI.

SysMod

Oral presentation

Toward a tidy package ecosystem for topological data analysis

In a special session on Expanding Tidyverse on June 23, Cory Brunson will discuss an open-source R package collection for TDA at the all-virtual useR! 2022.

cover-nerve

Oral Presentation

Post-Transplant Disparities Amongst Sarcoidosis-Indicated Lung Recipients

On Wednesday, May 18, Cory Brunson will give an oral presentation in a mini-symposium on Advances in Pre- and Post-Lung Transplant Care: From Selection to CLAD at the American Thoracic Society International Conference in San Francisco, CA.

1

Upcoming Seminars

October 6, 2022

Dr. Francesco Pappalardo

Universal Immune System Simulator applied to respiratory infectious diseases

Francesco Pappalardo

October 13, 2022 @ 9:30

Dr. Thomas Woolley

The Power of Noise

Thomas Woolley

Current Research Projects

Modular Design of Multi-scale Models

This project seeks to develop a novel approach to the modular design of multi-scale models using virtual machines and a user friendly open-source platform. Availability of biomedical data sets across spatial and temporal scales makes it possible to calibrate complex models that capture integrated processes from the molecular to the whole organism level.

1

Control of Biofilms

The project addresses an important biomedical problem: how to control biofilms formed by Candida albicans, a dimorphic fungus that is an important cause of both topical and systemic fungal infection in humans, in particular immunocompromised patients.

..

Battle Over Iron

Multiscale modeling of disease requires the integration of data at various spatiotemporal scales. Extending these models is often challenged by complex computational implementations and interdependencies between components of the model. In this project, we are developing a computational blueprint so that computational models can be developed in a modular fashion, while minimizing interdependencies between model components.

Capture

Network methods in biomedical research

Network analysis has gained popularity in systems medicine, though most applications have been “out of the box”. Cutting-edge network science draws from the rich history of graph theory and recent developments in statistical modeling and is aided by the speed, storage, and interoperability of computational resources. These distinctive research projects showcase the broader potential of network methods.

Trajectory image

we are hiring!

We are hiring!

The newly established Laboratory for Systems Medicine at University of Florida Health is focused on computational and mathematical approaches to human health.

Computational Research