
Welcome to the Laboratory for Systems Medicine
The newly established Laboratory for Systems Medicine at University of Florida Health is focused on computational and mathematical approaches to human health.

Systems medicine News
Funded Grant
Mechanistic Modeling of the Innate Immune Responses of the Human Lung to Understand the Inter-Individual Heterogeneity of COVID-19 Pneumonia
Drs. Laubenbacher and Mehrad received funding for a proposal to provide a mechanistic basis for the COVID-19 vast inter-individual heterogeneity by leveraging 3 key innovations.

JOURNAL ARTICLE
Development of a Risk Score to Increase Detection of Severe Alpha-1 Antitrypsin Deficiency
We study of the design and potential of a simple clinical risk score to prioritize screening for severe alpha-1 antitrypsin deficiency in the U.S. population.

Journal Article
Determining Optimal Combination Regimens for Patients with Multiple Myeloma
In this work, we use a mathematical modeling approach to determine combination therapy regimens that maximize healthy lifespan for patients with multiple myeloma.

Journal Article
COVID-19-associated pulmonary aspergillosis in immunocompetent patients: a virtual patient cohort study
This paper uses a computational model of innate immune response with virtual patient populations to explore hypothesized causes of COVID-19 Associated Pulmonary Aspergillosis in the absence of the conventional risk factors for invasive aspergillosis.

UPCOMING/RECENT PRESENTATIONS
Moderated Discussion
Research!America Alliance Discussion on Digital Twins
What is a digital twin? Learn more at this Research!America Alliance Discussion on June 15 @ 11:30 am – 12:00 pm.

Workshop Presentation
CompuCell3D: Overview and Applications in Complex Biological Systems Modeling
T.J. Sego showcased CompuCell3D, his software package for modeling cellular dynamics using a variety of simulation techniques. His talk surveyed CompuCell3D features and previous applications relevant to spatial and multiscale modeling of viral infection and immune response.

POSTER PRESENTATION
The Genetic Risk of Alzheimer’s Disorder is Associated with Decreased Risk of Hoarding Disorder
Luis Sordo Vieira co-authored a poster at the Society of Biological Psychiatry Annual Meeting in San Diego.

Poster Presentation
Can Non-Hoarding Specific Markers of Problems in Mental Health Predict Populations at Risk of Compulsive Hoarding?
Luis Sordo Vieira presented a poster at the Society of Biological Psychiatry Annual Meeting in San Diego.

Upcoming Seminars
October 5, 2023 @ 9:30am
Vincent Gureghian
A new role for interferon gamma in facilitating senescence escape in melanoma

November 28, 2023
Dr. Rachel Clipp
Towards a Human Physiological Digital Twin with the Pulse Physiology Engine

Current Research Projects
MARK TERASAKI, JASON CORY BRUNSON, KRISTINA SUAREZ
Structure and development of glomerular capillaries
Topological modeling and simulation lend insight into the structure, development, function, and resilience of glomerular capillary networks.

YARA SKAF, OSAMA DASA, JASON CORY BRUNSON
Exploring Clinical Outcomes using Topological Data Analysis
In this project, we demonstrate how topological data analysis can be used to visualize, explore, and characterize large and complex biomedical data such as electronic health records.

LUIS SORDO VIEIRA, CAROL A. MATHEWS
Predicting Populations At-Risk of Developing Pathological Hoarding
This study will identify risk-factors for developing troublesome hoarding by integrating and analyzing clinical interviews and a web-based registry of adults that includes various medical and cognitive questionnaires and neurocognitive.

HENRIQUE DE ASSIS L RIBEIRO, ADAM C KNAPP, LUIS L FONSECA
Multi-scale Modeling of the Immune Response to Aspergillus Fumigatus
Multi-scale agent-based modeling of the immune response and battle over iron in Aspergillus fumigatus infection.

we are hiring!
We are hiring!
The newly established Laboratory for Systems Medicine at University of Florida Health is focused on computational and mathematical approaches to human health.
